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Indicated for: Major Depressive Disorder (MDD), Depressive Episodes, Unipolar Depression, Anxiety Disorder associated with Depression, Generalized Anxiety Disorder (GAD), Chronic Primary Insomnia, Secondary Insomnia (particularly with SSRI-induced sleep disturbance), Obstructive Sleep Apnea (as an adjunct to reduce arousal threshold), Painful Diabetic Neuropathy, Fibromyalgia Syndrome, Post-Traumatic Stress Disorder (PTSD) (off-label for sleep disturbances), Behavioral and Psychological Symptoms of Dementia (BPSD) (for agitation/sleep).

 

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The Canadian clinical experience has demonstrated that the thoughtful use of Trazodone for anxiety in medically complex populations, with appropriate monitoring and dose adjustment, can provide meaningful symptom relief without the significant safety concerns that attend the use of alternative anxiolytic agents. The importance of this individualized approach cannot be overstated, as the same medication that produces dramatic improvement in one person may prove less suitable for another with a different symptom profile or medical history. The discontinuation of Trazodone can also produce withdrawal symptoms, including the anxiety, irritability, and insomnia that reflect the readjustment of the serotonergic and noradrenergic systems, though these symptoms are generally milder than those associated with Ambien withdrawal and can be managed through a gradual taper typically involving dose reductions of twenty-five milligrams every several days to weeks. Modafinil Provigil. The 100mg dose of Trazodone represents the typical dose range employed for this indication, as excessive sedation could theoretically worsen airway collapse while insufficient dosing would fail to provide the arousal threshold modulation that is the goal of treatment.

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