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Indicated for: Generalized Anxiety Disorder (GAD), Panic Disorder (Episodic Paroxysmal Anxiety), Anxiety Disorder due to Organic Condition (Organic Anxiety Disorder), Mixed Anxiety and Depressive Disorder (Anxiety Depression), Acute Stress Reaction (Acute Stress Disorder), Post-Traumatic Stress Disorder (PTSD), Insomnia of Nonorganic Origin due to Anxiety (Anxiety-Related Insomnia), Alcohol Withdrawal Syndrome with Psychomotor Agitation (Alcohol Withdrawal Delirium), Premedication for Surgical or Diagnostic Procedures (Preoperative Sedation), Status Epilepticus (as second-line therapy).

 

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The patient must be thoroughly educated about the specific properties of the medication they are taking, the expected duration of its effects, and the rationale for any proposed switch between benzodiazepine agents. Doses in excess of this 2 milligram per day threshold in an elderly patient are associated with a substantially and independently elevated risk of excessive and prolonged sedation, confusion, disorientation, cognitive impairment, ataxia, and the potentially life-altering and catastrophic consequence of a fall with resultant hip fracture, pelvic fracture, or traumatic brain injury. The Lorazepam is intended to serve as a temporary crutch, a pharmacological buffer that the patient can lean upon during the initial, turbulent weeks of SSRI initiation, but it is a crutch that is intended to be gradually and systematically removed as the patient's own intrinsic capacity for calm and stability is restored by the maturing therapeutic effects of the Zoloft. . When an individual consumes alcohol heavily and chronically over a prolonged period, the brain, ever the brilliant and adaptive organ, attempts to compensate for this constant chemical pressure by downregulating the sensitivity of GABA receptors and upregulating the activity of glutamate systems, essentially pushing back against the depressant effects in a valiant effort to maintain a functional level of baseline arousal and consciousness.

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