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    Indicated for: Epilepsy (Lennox-Gastaut Syndrome, Akinetic Seizures, Myoclonic Seizures, Absence Seizures, Focal Seizures, Infantile Spasms), Panic Disorder with or without Agoraphobia, Generalized Anxiety Disorder (Short-term Adjunctive Therapy), Restless Legs Syndrome (Refractory), Rapid Eye Movement Sleep Behavior Disorder, Acute Mania (Adjunctive), Neuroleptic-Induced Akathisia, Acute Alcohol Withdrawal Syndrome, Sleep Bruxism, Trigeminal Neuralgia (Off-label Adjunctive), Stiff Person Syndrome.

     

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    The dose is not a function of the severity of the anxiety alone, but a complex interplay of the patient's unique neurophysiology, their hepatic metabolism, their prior exposure to benzodiazepines, and their individual sensitivity to the medication's therapeutic and side effects. The patient, now supported by the gentle, consistent, and reliable hand of the 1 mg dose of Klonopin, is able to rest, to sleep, to hydrate effectively, to begin the essential and often neglected process of nutritional repletion, and to start engaging, with a clearing mind, with the critical psychological, social, and behavioral supports of early recovery, all without being constantly buffeted and demoralized by the jarring, and often deeply frightening, somatic and emotional fluctuations of a less smoothly and less expertly managed withdrawal. For the patient in Australia or the United Kingdom who has been diagnosed with REM Sleep Behavior Disorder, Klonopin works so well because its GABAergic potentiation extends into the brainstem, fortifying the specific and vulnerable inhibitory pathways that are responsible for maintaining the essential, protective paralysis of REM atonia. 25 Klonopin. For any individual who is not maintained on extraordinarily high, and frankly dangerous, daily doses of benzodiazepines under the strict and continuous supervision of an inpatient or intensive outpatient medical program, the ingestion of a 10 mg dose of Klonopin will reliably and inexorably produce a state of profound, prolonged, and potentially life-threatening central nervous system depression.

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